Meloxicam

A to Z Drug Facts

Meloxicam

	Action
	Indications
	Contraindications
	Route/Dosage
	Interactions
	Adverse Reactions
	Precautions
Patient Care Considerations
	Administration/Storage
	Assessment/Interventions
	Patient/Family Education

(mell-ox-ih-kam)

Mobic

Class: Analgesic/NSAID

Action Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Indications Relief of signs and symptoms of osteoarthritis.

Contraindications Hypersensitivity to aspirin or any other NSAID.

Route/Dosage

7.5 to 15 mg once daily (maximum 15 mg/day).

Interactions

ACE inhibitors (eg, captopril): Antihypertensive effects may be decreased. Aspirin: Additive GI toxicity. Cholestyramine: Plasma levels of meloxicam may be reduced. Loop diuretics (eg, furosemide), thiazide diuretics (eg, chlorothiazide): Diuretic effects may be decreased. Lithium: May increase lithium levels. Warfarin: May increase risk of gastric erosion and bleeding. Lab Test Interferences: None well documented.

Adverse Reactions

CV: Arrhythmia; palpitation; tachycardia. DERM: Rash; pruritus; alopecia; angioedema; bullous eruption; erythema multiforme; photosensitivity; Stevens-Johnson syndrome; sweating; toxic epidermal necrolysis; urticaria. EENT: Pharyngitis; esophagitis; abnormal vision; conjunctivitis; taste perversion; innitus. GI: Abdominal pain; diarrhea; nausea; constipation; dyspepsia; flatulence; omiting; colitis; dry mouth; duodenal ulcer; eructation; gastric ulcer; intestinal perforation; melena; pancreatitis; perforated duodenal and gastric ulcers; lcerative stomatitis. GU: Micturition frequency; urinary tract infection; albuminuria; increased BUN and creatinine; hematuria; interstitial nephritis; renal failure. HEMA: Anemia; agranulocytosis; leukopenia; purpura; thrombocytopenia; ilirubinemia. HEPA: Increased ALT and AST; hepatitis; jaundice; liver failure. META: Edema; dehydration. RESP: Upper respiratory tract infection; coughing; asthma; bronchospasm; yspnea. OTHER: Falling; flu-like symptoms; pain; arthralgia; back pain; anaphylactoid reactions.

Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly: Use with caution. Cardiovascular disease: Since fluid retention and edema can occur; use with caution in patients with fluid retention, hypertension, or heart failure. GI effects: Serious GI toxicity (eg, bleeding, ulceration, perforation) can occur at any time, with or without warning signs. Hepatic impairment: Assess liver function while on therapy. Renal impairment: Assess function before and during therapy because NSAID metabolites are eliminated by the kidney.

PATIENT CARE CONSIDERATIONS

Administration/Storage

Assessment/Interventions

OVERDOSAGE: SIGNS & SYMPTOMS
	Lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding, hypertension, acute renal failure, hepatic dysfunction, respiratory depression, coma, convulsions, cardiovascular collapse, cardiac arrest

Patient/Family Education